Effects of 5α-dihydrotestosterone on the modulation of monocyte/macrophage response to Staphylococcus aureus: an in vitro study

Effects of 5α-dihydrotestosterone on the modulation of monocyte/macrophage response to Staphylococcus aureus: an in vitro study

Highlights A sex difference in the immune response to S. aureus was observed. DHT stimulated a greater release of inflammatory cytokines. DHT promoted the activation of genes involved in this response. DHT suppressed the release of inflammatory markers.

Bibliographic Details
Main Authors: Déborah Cruz Dos Santos, Rafaela de Souza Bittencout, Iago Dórea Arêas, Larissa Silva C. Pena, Carolline Florentino Almeida, Bruna Carolina de Brito Guimarães, Rafael Santos Dantas Miranda Dórea, Thiago Macêdo Lopes Correia, Manoel Neres Santos Júnior, Lorena Lôbo Brito Morbeck, Talita Costa Dos Santos, Clarissa Leal S. Souza, Samira Itana de Souza, Telma de Jesus Soares, Regiane Yatsuda, Guilherme Barreto Campos, Lucas Miranda Marques
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Biology of Sex Differences
Subjects:
5α-Dihydrotestosterone
Staphylococcus aureus
Inflammatory response
Online Access:https://doi.org/10.1186/s13293-023-00501-2

Internet

https://doi.org/10.1186/s13293-023-00501-2

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