STING-mediated intestinal barrier dysfunction contributes to lethal sepsisResearch in context

Background: Gut integrity is compromised in abdominal sepsis with increased cellular apoptosis and altered barrier permeability. Intestinal epithelial cells (IEC) form a physiochemical barrier that separates the intestinal lumen from the host's internal milieu and is strongly involved in the mu...

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Bibliographic Details
Main Authors: Qiongyuan Hu, Huajian Ren, Guanwei Li, Dingyu Wang, Quan Zhou, Jie Wu, Jiashuo Zheng, Jinjian Huang, Dominic A. Slade, Xiuwen Wu, Jianan Ren
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419301343