7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a “Cut and Glue” Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors

7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a “Cut and Glue” Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors

Although overexpression and hyperactivity of protein kinases are causative for a wide range of human cancers, protein kinase inhibitors currently approved as cancer drugs address only a limited number of these enzymes. To identify new chemotypes addressing alternative protein kinases, the basic stru...

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Bibliographic Details
Main Authors: Mehmet Karatas, Apirat Chaikuad, Bianca Berger, Michael H. G. Kubbutat, Frank Totzke, Stefan Knapp, Conrad Kunick
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
anilinopyrimidine
Aurora kinase
benzazepinone
molecular docking
protein kinase inhibitor
sulfamide
Online Access:https://www.mdpi.com/1420-3049/26/6/1611

Internet

https://www.mdpi.com/1420-3049/26/6/1611

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