Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model

Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model

<p>Abstract</p> <p>Background</p> <p>Despite recent advances in the treatment of hepatocellular carcinoma (HCC), the chemotherapy efficacy against HCC is still unsatisfactory. The mammalian target of rapamycin (mTOR) has been emerged as an important cancer therapeutic t...

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Bibliographic Details
Main Authors: Wang Cun, Gao Dongmei, Guo Kun, Kang Xiaonan, Jiang Kai, Sun Chun, Li Yan, Sun Lu, Shu Hong, Jin Guangzhi, Sun Haiyan, Wu Weizhong, Liu Yinkun
Format: Article
Language:English
Published: BMC 2012-05-01
Series:BMC Cancer
Subjects:
Rapamycin
Bortezomib
mTOR
Akt
Hepatocellular carcinoma
Online Access:http://www.biomedcentral.com/1471-2407/12/166

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http://www.biomedcentral.com/1471-2407/12/166

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