Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model

Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model

<p>Abstract</p> <p>Background</p> <p>Despite recent advances in the treatment of hepatocellular carcinoma (HCC), the chemotherapy efficacy against HCC is still unsatisfactory. The mammalian target of rapamycin (mTOR) has been emerged as an important cancer therapeutic t...

Full description

Bibliographic Details
Main Authors:	Wang Cun, Gao Dongmei, Guo Kun, Kang Xiaonan, Jiang Kai, Sun Chun, Li Yan, Sun Lu, Shu Hong, Jin Guangzhi, Sun Haiyan, Wu Weizhong, Liu Yinkun
Format:	Article
Language:	English
Published:	BMC 2012-05-01
Series:	BMC Cancer
Subjects:	Rapamycin Bortezomib mTOR Akt Hepatocellular carcinoma
Online Access:	http://www.biomedcentral.com/1471-2407/12/166

Similar Items

Rapamycin-Loaded Lipid Nanocapsules Induce Selective Inhibition of the mTORC1-Signaling Pathway in Glioblastoma Cells
by: Delphine Séhédic, et al.
Published: (2021-02-01)

Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo
by: Linyan Zhou, et al.
Published: (2017-08-01)

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver
by: Luise Spormann, et al.
Published: (2020-07-01)

Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration
by: Masoud Razmara, et al.
Published: (2018-10-01)

Advances in the mTOR signaling pathway and its inhibitor rapamycin in epilepsy
by: Wei Zhao, et al.
Published: (2023-06-01)

Assessing the effectiveness of rapamycin on angiomyolipoma in tuberous sclerosis: a two years trial
by: Cabrera-López Cristina, et al.
Published: (2012-11-01)

Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks
by: Vincenzo Sorrenti, et al.
Published: (2022-07-01)

Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin
by: Slingluff Craig L, et al.
Published: (2005-10-01)

Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer
by: Chen YQ, et al.
Published: (2021-01-01)

A pulse rapamycin therapy for infantile spasms and associated cognitive decline
by: Emmanuel Raffo, et al.
Published: (2011-08-01)

Antiepileptic Effect and Safety Profile of Rapamycin in Pediatric Patients With Tuberous Sclerosis Complex
by: Krzysztof Sadowski, et al.
Published: (2022-04-01)

Therapeutic Effect of Rapamycin on Aortic Dissection in Mice
by: Makiko Hayashi-Hori, et al.
Published: (2020-05-01)

Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
by: Belinda Seto
Published: (2012-12-01)

Rapamycin Promotes the Expansion of Myeloid Cells by Increasing G-CSF Expression in Mesenchymal Stem Cells
by: Minghao Li, et al.
Published: (2022-03-01)

The protective effects of rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mTOR-S6K1-LC3II signaling pathway
by: Lei Liu, et al.
Published: (2018-10-01)

Role for Target of Rapamycin (mTOR) Signal Pathway in Regulating Neuronal Injury after Intracerebral Hemorrhage
by: Jie-Ping Wang, et al.
Published: (2017-01-01)

AKT–THE MAMMALIAN TARGET OF RAPAMYCIN (MTOR) PATHWAY INHIBITION INCREASES CERVICAL CANCER CELL CHEMOSENSITIVITY TO ACTIVE FORM OF IRINOTECAN (SN-38)
by: Leri Septiani, et al.
Published: (2015-07-01)

Rapamycin Rescues the Poor Developmental Capacity of Aged Porcine Oocytes
by: Seung Eun Lee, et al.
Published: (2014-05-01)

Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system
by: Jing eJiang, et al.
Published: (2013-08-01)

Autophagy induction by endothelial-monocyte activating polypeptide II contributes to the inhibition of malignant biological behaviors by the combination of EMAP II with rapamycin in human glioblastoma
by: Jun eMa, et al.
Published: (2015-12-01)

Tribbles Pseudokinase 3 Regulation and Contribution to Cancer
by: Bojana Stefanovska, et al.
Published: (2021-04-01)

Regulation of osteoblast autophagy based on PI3K/AKT/mTOR signaling pathway study on the effect of β-ecdysterone on fracture healing
by: Yanghua Tang, et al.
Published: (2021-12-01)

Short‐term rapamycin administration elevated testosterone levels and exacerbated reproductive disorder in dehydroepiandrosterone‐induced polycystic ovary syndrome mice
by: Zaixin Guo, et al.
Published: (2021-05-01)

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
by: Antonella Tramutola, et al.
Published: (2018-11-01)

The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts
by: Vedad Delic, et al.
Published: (2018-11-01)

Effects of Monensin and Rapamycin Combination Therapy on Tumor Growth and Apoptosis in a Xenograft Mouse Model of Neuroblastoma
by: Sema Serter Kocoglu, et al.
Published: (2023-06-01)

Active Mechanistic Target of Rapamycin plays an ancillary rather than essential role in Zebrafish CNS axon regeneration
by: Heike eDiekmann, et al.
Published: (2015-07-01)

Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation
by: Qiyu Yang, et al.
Published: (2022-04-01)

Isolated Components From Spider Venom Targeting Human Glioblastoma Cells and Its Potential Combined Therapy With Rapamycin
by: Marcus Caballero, et al.
Published: (2022-03-01)

mTOR inhibition: a promise for a young heart.
by: Stêfany Bruno De Assis Cau, et al.
Published: (2012-02-01)

A New Hypothesis Describing the Pathogenesis of Oral Mucosal Injury Associated with the Mammalian Target of Rapamycin (mTOR) Inhibitors
by: Stephen T. Sonis, et al.
Published: (2023-12-01)

Single-Dose Treatment with Rapamycin Preserves Post-Ischemic Cardiac Function through Attenuation of Fibrosis and Inflammation in Diabetic Rabbit
by: Arun Samidurai, et al.
Published: (2023-05-01)

Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder
by: D. Iezzi, et al.
Published: (2022-09-01)

mTOR Inhibition via Low-Dose, Pulsed Rapamycin with Intraovarian Condensed Platelet Cytokines: An Individualized Protocol to Recover Diminished Reserve?
by: E. Scott Sills, et al.
Published: (2023-07-01)

Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation
by: Takashi Yurube, et al.
Published: (2024-03-01)

Rapamycin: Drug Repurposing in SARS-CoV-2 Infection
by: Jiri Patocka, et al.
Published: (2021-03-01)

Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero
by: Hiroko Kotajima-Murakami, et al.
Published: (2019-01-01)

Rapamycin as an Adjunctive Therapy for NLRC4 Associated Macrophage Activation Syndrome
by: Julie Barsalou, et al.
Published: (2018-09-01)

Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling
by: Xi-Gong Li, et al.
Published: (2019-01-01)

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
by: Lan eYe, et al.
Published: (2012-09-01)