Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo LipogenesisSummary

Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo LipogenesisSummary

Background & Aims: Dysregulation of liver lipid metabolism is associated with the development and progression of nonalcoholic fatty liver disease, a spectrum of liver diseases including nonalcoholic steatohepatitis (NASH). In the liver, insulin controls lipid homeostasis by increasing trigly...

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Bibliographic Details
Main Authors: Kahealani Uehara, Jaimarie Sostre-Colón, Matthew Gavin, Dominic Santoleri, Kelly-Ann Leonard, René L. Jacobs, Paul M. Titchenell
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
CCTα
FOXO1
Insulin
Nonalcoholic Fatty Liver Disease
Phosphatidylcholine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X2200042X

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X2200042X

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