Investigating Two Modes of Cancer-Associated Antigen Heterogeneity in an Agent-Based Model of Chimeric Antigen Receptor T-Cell Therapy

Investigating Two Modes of Cancer-Associated Antigen Heterogeneity in an Agent-Based Model of Chimeric Antigen Receptor T-Cell Therapy

Chimeric antigen receptor (CAR) T-cell therapy has been successful in treating liquid tumors but has had limited success in solid tumors. This work examines unanswered questions regarding CAR T-cell therapy using computational modeling, such as, what percentage of the tumor must express cancer-assoc...

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Bibliographic Details
Main Authors: Tina Giorgadze, Henning Fischel, Ansel Tessier, Kerri-Ann Norton
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
computational model
agent-based model
tumor heterogeneity
triple-negative breast cancer
cancer stem cells
CAR T-cells
Online Access:https://www.mdpi.com/2073-4409/11/19/3165

Internet

https://www.mdpi.com/2073-4409/11/19/3165

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