Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP
Mutations in two related genes,presenilin 1andpresenilin 2(PS1andPS2), cosegregate with Alzheimer's disease. PS1 and PS2 are highly homologous polytopic membrane proteins that are subject to endoproteolytic cleavagein vivo.The resulting N- and C-terminal derivatives are the preponderant PS-rela...
| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Elsevier
1998-01-01
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| coleção: | Neurobiology of Disease |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S0969996198901711 |