Pembrolizumab in Advanced Gastrointestinal Malignancies with Defective DNA Mismatch Repair: A Case Series

Pembrolizumab in Advanced Gastrointestinal Malignancies with Defective DNA Mismatch Repair: A Case Series

Background: Tumors with deficient mismatch repair (dMMR) have a favorable immunological phenotype permitting exploitation by immunotherapies. We aimed to assess our institutional experience of dMMR advanced gastrointestinal (GI) cancers treated with the PD-1 inhibitor pembrolizumab. Materials and Me...

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Bibliographic Details
Main Authors: David D Stenehjem, Courtney C Cavalieri, Eric Swanson, Benjamin Solomon, Jonathan Whisenant, Dao Tran, John Weis, G Weldon Gilcrease, Sunil Sharma, Ignacio Garrido-Laguna
Format: Article
Language:English
Published: Innovative Healthcare Institute 2018-07-01
Series:Journal of Immunotherapy and Precision Oncology
Subjects:
case series
defective dna mismatch repair
gastrointestinal malignancies
immunotherapy
pembrolizumab
Online Access:https://jipo.org/doi/pdf/10.4103/JIPO.JIPO_5_1

Internet

https://jipo.org/doi/pdf/10.4103/JIPO.JIPO_5_1

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