Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies

Large-scale insecticide application is a primary weapon in the control of insect pests in agriculture. However, a growing body of evidence indicates that it is contributing to the global decline in population sizes of many beneficial insect species. Spinosad emerged as an organic alternative to synt...

Full description

Bibliographic Details
Main Authors: Felipe Martelli, Natalia H Hernandes, Zhongyuan Zuo, Julia Wang, Ching-On Wong, Nicholas E Karagas, Ute Roessner, Thusita Rupasinghe, Charles Robin, Kartik Venkatachalam, Trent Perry, Philip Batterham, Hugo J Bellen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/73812