Dipeptidyl peptidase IV inhibition exerts renoprotective effects in rats with established heart failure

Dipeptidyl peptidase IV inhibition exerts renoprotective effects in rats with established heart failure

Circulating dipeptidyl peptidase IV (DPPIV) activity is associated with worse cardiovascular outcomes in humans and experimental heart failure (HF) models, suggesting that DPPIV may play a role in the pathophysiology of this syndrome. Renal dysfunction is one of the key features of HF, but it remain...

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Bibliographic Details
Main Authors: Daniel Francisco De Arruda Junior, Flávia Letícia Martins, Rafael Dariolli, Leonardo Jensen Socas, Ednei Luiz Antonio, Leonardo Dos Santos, Paulo José Ferreira Tucci, Adriana Castello Costa Girardi
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Physiology
Subjects:
Glucagon-Like Peptide 1
fluid retention
Megalin
vildagliptin
proteinuria.
cardiorenal dysfunction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00293/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00293/full

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