Injection site vaccinology of a recombinant vaccinia-based vector reveals diverse innate immune signatures.

Injection site vaccinology of a recombinant vaccinia-based vector reveals diverse innate immune signatures.

Poxvirus systems have been extensively used as vaccine vectors. Herein a RNA-Seq analysis of intramuscular injection sites provided detailed insights into host innate immune responses, as well as expression of vector and recombinant immunogen genes, after vaccination with a new multiplication defect...

Full description

Bibliographic Details
Main Authors: Jessamine E Hazlewood, Troy Dumenil, Thuy T Le, Andrii Slonchak, Stephen H Kazakoff, Ann-Marie Patch, Lesley-Ann Gray, Paul M Howley, Liang Liu, John D Hayball, Kexin Yan, Daniel J Rawle, Natalie A Prow, Andreas Suhrbier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009215

Internet

https://doi.org/10.1371/journal.ppat.1009215

Similar Items