Positively Selected Sites at HCMV gB Furin Processing Region and Their Effects in Cleavage Efficiency

Positively Selected Sites at HCMV gB Furin Processing Region and Their Effects in Cleavage Efficiency

Human cytomegalovirus is a ubiquitous infectious agent that affects mainly immunosuppressed, fetuses, and newborns. The virus has several polymorphic regions, in particular in the envelope glycoproteins. The UL55 gene encodes the glycoprotein B that has a variable region, containing a furin cleavage...

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Bibliographic Details
Main Authors: Lucas M. Stangherlin, Felipe N. de Paula, Marcelo Y. Icimoto, Leonardo G. P. Ruiz, Maurício L. Nogueira, Antônio S. K. Braz, Luiz Juliano, Maria C. C. da Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Microbiology
Subjects:
human cytomegalovirus
glycoprotein B
selective pressure
furin cleavage
gB genotypes
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00934/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.00934/full

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