Histone chaperone ASF1A accelerates chronic myeloid leukemia blast crisis by activating Notch signaling

Histone chaperone ASF1A accelerates chronic myeloid leukemia blast crisis by activating Notch signaling

Abstract The blast crisis (BC) is the final deadly phase of chronic myeloid leukemia (CML), which remains a major challenge in clinical management. However, the underlying molecular mechanism driving blastic transformation remains unclear. Here, we show that ASF1A, an essential activator, enhanced t...

Full description

Bibliographic Details
Main Authors: Xiaolin Yin, Minran Zhou, Lu Zhang, Yue Fu, Man Xu, Xiaoming Wang, Zelong Cui, Zhenxing Gao, Miao Li, Yuting Dong, Huimin Feng, Sai Ma, Chunyan Chen
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05234-5

Internet

https://doi.org/10.1038/s41419-022-05234-5

Similar Items