ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes

ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes

High levels of expression of the ATP binding cassette transporter A1 (ABCA1) in the liver and the need to over- or underexpress hepatic ABCA1 to impact plasma HDL levels in mice suggest a major role of the liver in HDL formation and in determining circulating HDL levels. Cultured murine hepatocytes...

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Bibliographic Details
Main Authors: Daisy Sahoo, Timothy C. Trischuk, Teddy Chan, Victor A.B. Drover, Samuel Ho, Giovanna Chimini, Luis B. Agellon, Ricky Agnihotri, Gordon A. Francis, Richard Lehner
Format: Article
Language:English
Published: Elsevier 2004-06-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter A1
atherosclerosis
cholesterol
efflux
triacylglycerol
triglyceride
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520318101

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http://www.sciencedirect.com/science/article/pii/S0022227520318101

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