Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi

Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi

Gene drives may be impeded by the generation of resistant alleles following NHEJ. Here the authors develop a recoded gene-drive rescue system for the malaria mosquito, Anopheles stephensi, that targets the drive to the kynurenine hydroxylase gene for negative selection against mutated alleles.

Bibliographic Details
Main Authors: Adriana Adolfi, Valentino M. Gantz, Nijole Jasinskiene, Hsu-Feng Lee, Kristy Hwang, Gerard Terradas, Emily A. Bulger, Arunachalam Ramaiah, Jared B. Bennett, J. J. Emerson, John M. Marshall, Ethan Bier, Anthony A. James
Format: Article
Language:English
Published: Nature Portfolio 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19426-0

Internet

https://doi.org/10.1038/s41467-020-19426-0

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