Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
Gene drives may be impeded by the generation of resistant alleles following NHEJ. Here the authors develop a recoded gene-drive rescue system for the malaria mosquito, Anopheles stephensi, that targets the drive to the kynurenine hydroxylase gene for negative selection against mutated alleles.
Bibliographic Details
| Main Authors: |
Adriana Adolfi,
Valentino M. Gantz,
Nijole Jasinskiene,
Hsu-Feng Lee,
Kristy Hwang,
Gerard Terradas,
Emily A. Bulger,
Arunachalam Ramaiah,
Jared B. Bennett,
J. J. Emerson,
John M. Marshall,
Ethan Bier,
Anthony A. James |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-19426-0
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