Mutant Cytochrome C as a Potential Detector of Superoxide Generation: Effect of Mutations on the Function and Properties

Mutant Cytochrome C as a Potential Detector of Superoxide Generation: Effect of Mutations on the Function and Properties

Cytochrome c (CytC) is a single-electron carrier between complex bc1 and cytochrome c-oxidase (CcO) in the electron transport chain (ETC). It is also known as a good radical scavenger but its participation in electron flow through the ETC makes it impossible to use CytC as a radical sensor. To solve...

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Bibliographic Details
Main Authors: Rita V. Chertkova, Ilya P. Oleynikov, Alexey A. Pakhomov, Roman V. Sudakov, Victor N. Orlov, Marina A. Semenova, Alexander M. Arutyunyan, Vasily V. Ptushenko, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh, Tatiana V. Vygodina
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cells
Subjects:
electron transport chain
mitochondrial cytochrome <i>c</i>
heme
cytochrome <i>c</i> oxidase
universal binding site
red Ω-loop of cytochrome <i>c</i>
Online Access:https://www.mdpi.com/2073-4409/12/18/2316

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https://www.mdpi.com/2073-4409/12/18/2316

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