Splice-Variant Knock-Out of TGFβ Receptors Perturbates the Proteome of Ovarian Carcinoma Cells

Splice-Variant Knock-Out of TGFβ Receptors Perturbates the Proteome of Ovarian Carcinoma Cells

The aim of this study was to analyze the biological role of different transforming growth factor-β (TGFβ) receptor splice variants in ovarian carcinoma (OC). Specific receptor variant knockouts (KO) were prepared using the CRISPR/Cas9 genome editing system in two OC cell lines, TβRI variant 1 (TβRIv...

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Bibliographic Details
Main Authors: Liora Jacobs Catane, Ofra Moshel, Yoav Smith, Ben Davidson, Reuven Reich
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
transforming growth factor-β
TGFβ
receptor splice variants
ovarian carcinoma
proteomics
CRISPR/Cas9 KO’s
Online Access:https://www.mdpi.com/1422-0067/22/23/12647

Internet

https://www.mdpi.com/1422-0067/22/23/12647

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