Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis

Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis

Venezuelan equine encephalitis virus (VEEV), a mosquito transmitted alphavirus of the <i>Togaviridae</i> family, can cause a highly inflammatory and encephalitic disease upon infection. Although a category B select agent, no FDA-approved vaccines or therapeutics against VEEV currently ex...

Full description

Bibliographic Details
Main Authors: Allison Bakovic, Nishank Bhalla, Stephanie Kortchak, Chengqun Sun, Weidong Zhou, Aslaa Ahmed, Kenneth Risner, William B. Klimstra, Aarthi Narayanan
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Viruses
Subjects:
Venezuelan equine encephalitis virus
phosphorylation
IKK complex
IKKβ kinase assay
replication-deficient
non-structural protein 3
Online Access:https://www.mdpi.com/1999-4915/12/9/1021

Internet

https://www.mdpi.com/1999-4915/12/9/1021

Similar Items