Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection

Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection

Cognitive dysfunction persists in 30–50% of chronically HIV-infected individuals despite combination antiretroviral therapy (ART). Although monocytes are implicated in poor cognitive performance, distinct biological mechanisms associated with cognitive dysfunction in HIV infection are unclear. We pr...

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Bibliographic Details
Main Authors: Michelle L. D'Antoni, Kalpana J. Kallianpur, Thomas A. Premeaux, Michael J. Corley, Tsuyoshi Fujita, Elizabeth I. Laws, Debra Ogata-Arakaki, Dominic C. Chow, Vedbar S. Khadka, Cecilia M. Shikuma, Lishomwa C. Ndhlovu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
HIV-1
IRF-8
interferon
monocytes
dendritic cells
cognition
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02789/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02789/full

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