Sperm chromatin accessibility’s involvement in the intergenerational effects of stress hormone receptor activation

Abstract Dexamethasone is a stress hormone receptor agonist used widely in clinics. We and others previously showed that paternal administration of dexamethasone in mice affects the phenotype of their offspring. The substrate of intergenerational transmission of environmentally induced effects often...

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Bibliographic Details
Main Authors: Vincent Fischer, Miriam Kretschmer, Pierre-Luc Germain, Jasmine Kaur, Sergio Mompart-Barrenechea, Pawel Pelczar, David Schürmann, Primo Schär, Katharina Gapp
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02684-z