Cardioprotective Effects of n-3 Polyunsaturated Fatty Acids: Orchestration of mRNA Expression, Protein Phosphorylation, and Lipid Metabolism in Pressure Overload Hearts

Cardioprotective Effects of n-3 Polyunsaturated Fatty Acids: Orchestration of mRNA Expression, Protein Phosphorylation, and Lipid Metabolism in Pressure Overload Hearts

Background: Pressure overload can result in dilated cardiomyopathy. The beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFAs) on heart disorders have been widely recognized. However, the molecular mechanisms underlying their protective effects against cardiomyopathy remain unclear.Method...

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Bibliographic Details
Main Authors: Xiang Li, Weijiang Tan, Shuang Zheng, Junjie Zhang, Caiyi Zhu, Chun Cai, Honghua Chen, Chenqi Yang, Le Kang, Zhanhong Pan, W. Glen Pyle, Peter H. Backx, Yunzeng Zou, Feng Hua Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
n-3 PUFA
pressure overload
dilated cardiomyopathy cardioprotection
mitochondrial function
multi-omics analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.788270/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.788270/full

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