Cytokine Release Syndrome and Associated Acute Toxicities in Pediatric Patients Undergoing Immune Effector Cell Therapy or Hematopoietic Cell Transplantation

Cytokine Release Syndrome and Associated Acute Toxicities in Pediatric Patients Undergoing Immune Effector Cell Therapy or Hematopoietic Cell Transplantation

Immune effector cells (IEC) are a powerful and increasingly targeted tool, particularly for the control and eradication of malignant diseases. However, the infusion, expansion, and persistence of autologous or allogeneic IEC or engagement of endogenous immune cells can be associated with significant...

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Bibliographic Details
Main Authors: Susanne H. C. Baumeister, Gopi S. Mohan, Alaa Elhaddad, Leslie Lehmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
cytokine release syndrome (CRS)
immune effector cell associated neurotoxicity syndrome (ICANS)
immune effector cells (IEC)
CAR T cells
blinatumomab
pediatric hematopoietic cell transplantation (HCT)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.841117/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.841117/full

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