An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T Cells Controls Obesity-Induced Inflammation

An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T Cells Controls Obesity-Induced Inflammation

An adaptive immune response triggered by obesity is characterized by the activation of adipose tissue CD4+ T cells by unclear mechanisms. We have examined whether interactions between adipose tissue macrophages (ATMs) and CD4+ T cells contribute to adipose tissue metainflammation. Intravital microsc...

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Bibliographic Details
Main Authors: Kae Won Cho, David L. Morris, Jennifer L. DelProposto, Lynn Geletka, Brian Zamarron, Gabriel Martinez-Santibanez, Kevin A. Meyer, Kanakadurga Singer, Robert W. O’Rourke, Carey N. Lumeng
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714007724

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http://www.sciencedirect.com/science/article/pii/S2211124714007724

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