Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model

Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model

Chimeric antigen receptor T cells (CAR-T) utilize T cell receptor (TCR) signaling cascades and the recognition functions of antibodies. This allows T cells, normally restricted by the major histocompatibility complex (MHC), to be redirected to target cells by their surface antigens, such as tumor as...

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Bibliographic Details
Main Authors: Ling Wu, Joanna Brzostek, Shvetha Sankaran, Qianru Wei, Jiawei Yap, Triscilla Y.Y. Tan, Junyun Lai, Paul A. MacAry, Nicholas R. J. Gascoigne
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
T cell receptor
chimeric antigen receptor (CAR) T cell (CAR-T)
signal transduction
CD8 coreceptor
signaling kinetics
oligomerization
Online Access:https://www.mdpi.com/2072-6694/13/4/867

Internet

https://www.mdpi.com/2072-6694/13/4/867

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