Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis

Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis

Abstract Background Metastatic colonization is one of the critical steps in tumor metastasis. A pre-metastatic niche is required for metastatic colonization and is determined by tumor-stroma interactions, yet the mechanistic underpinnings remain incompletely understood. Methods PCR-based miRNome pro...

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Bibliographic Details
Main Authors: Yulan Mo, Leanne L. Leung, Celia S. L. Mak, Xueyu Wang, Wai-Sun Chan, Lynn M. N. Hui, Hermit W. M. Tang, Michelle K. Y. Siu, Rakesh Sharma, Dakang Xu, Stephen K. W. Tsui, Hextan Y. S. Ngan, Mingo M. H. Yung, Karen K. L. Chan, David W. Chan
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Cancer
Subjects:
miR-141
Hippo/YAP1/pathway
Ovarian cancer
Tumor-stroma interactions
Peritoneal metastases
cancer-associated fibroblasts
Online Access:https://doi.org/10.1186/s12943-022-01703-9

Internet

https://doi.org/10.1186/s12943-022-01703-9

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