Neuroinflammation regulates the balance between hippocampal neuron death and neurogenesis in an ex vivo model of thiamine deficiency

Neuroinflammation regulates the balance between hippocampal neuron death and neurogenesis in an ex vivo model of thiamine deficiency

Abstract Background Thiamine (vitamin B1) is a cofactor for enzymes of central energy metabolism and its deficiency (TD) impairs oxidative phosphorylation, increases oxidative stress, and activates inflammatory processes that can lead to neurodegeneration. Wernicke–Korsakoff syndrome (WKS) is a cons...

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Bibliographic Details
Main Authors: Larissa M. G. Cassiano, Marina S. Oliveira, Jeanne Pioline, Anna C. M. Salim, Roney S. Coimbra
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Neuroinflammation
Subjects:
Thiamine deficiency
Organotypic hippocampal culture
Neurogenesis. inflammation
Neurodegeneration
Neuroregeneration
Online Access:https://doi.org/10.1186/s12974-022-02624-6

Internet

https://doi.org/10.1186/s12974-022-02624-6

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