Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases

Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases

Highlights Quantitative proteomics is a useful approach to biochemically characterize the pathological neurodegeneration that occurs at the level of olfactory areas. Alteration in the olfactory tract proteostasis is more severe in AD than in PD. Protein expression changes are more abundant in women...

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Bibliographic Details
Main Authors: Paz Cartas-Cejudo, Mercedes Lachén-Montes, Isidro Ferrer, Joaquín Fernández-Irigoyen, Enrique Santamaría
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Biology of Sex Differences
Subjects:
Sirtuin
Olfaction
Sexual dimorphism
Alzheimer
Parkinson
Proteomics
Online Access:https://doi.org/10.1186/s13293-023-00487-x

Internet

https://doi.org/10.1186/s13293-023-00487-x

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