UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

Accumulating evidence indicates that the lysosomal Ragulator complex is essential for full activation of the mechanistic target of rapamycin complex 1 (mTORC1). Abnormal mTORC1 activation has been implicated in several developmental neurological disorders, including Angelman syndrome (AS), which is...

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Bibliographic Details
Main Authors: Jiandong Sun, Yan Liu, Yousheng Jia, Xiaoning Hao, Wei ju Lin, Jennifer Tran, Gary Lynch, Michel Baudry, Xiaoning Bi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
Angelman syndrome
arc
LTP
lysosome
proteasome
protein synthesis
Online Access:https://elifesciences.org/articles/37993

Internet

https://elifesciences.org/articles/37993

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