TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling

TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling

Background & Aims: Oxidative stress-mediated ferroptosis and macrophage-related inflammation play an important role in various liver diseases. Here, we explored if and how hepatocyte ferroptosis regulates macrophage stimulator of interferon genes (STING) activation in the development of spon...

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Bibliographic Details
Main Authors: Wantong Su, Weicheng Gao, Rui Zhang, Qi Wang, Lei Li, Qingfa Bu, Zibo Xu, Zheng Liu, Mingming Wang, Yaqing Zhu, Guoping Wu, Haoming Zhou, Xun Wang, Ling Lu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:JHEP Reports
Subjects:
TAK1
STING
Oxidative stress
Ferroptosis
Tumorigenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923000265

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http://www.sciencedirect.com/science/article/pii/S2589555923000265

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