Autophagy regulates lipid metabolism through selective turnover of NCoR1

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Defective autophagy has been associated with metabolic disorders. Here Saito et al. show that autophagy promotes the selective degradation of NCoR1, a repressor of lipid metabolism regulator PPARα, in response to starvation, and thus induces the expression of enzymes involved in lipid oxidation and...

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Dades bibliogràfiques
Autors principals: Tetsuya Saito, Akiko Kuma, Yuki Sugiura, Yoshinobu Ichimura, Miki Obata, Hiroshi Kitamura, Shujiro Okuda, Hyeon-Cheol Lee, Kazutaka Ikeda, Yumi Kanegae, Izumu Saito, Johan Auwerx, Hozumi Motohashi, Makoto Suematsu, Tomoyoshi Soga, Takehiko Yokomizo, Satoshi Waguri, Noboru Mizushima, Masaaki Komatsu
Format: Article
Idioma:English
Publicat: Nature Portfolio 2019-04-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-019-08829-3

Internet

https://doi.org/10.1038/s41467-019-08829-3

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