Postural Change-associated Alterations in QT/QTc Intervals on Electrocardiograms

Postural Change-associated Alterations in QT/QTc Intervals on Electrocardiograms

In a new drug development, regulatory authorities recommend the “thorough QT/QTc study”, in which the use of a positive control group was recommended for evaluating assay sensitivity that allows the detection of a QT/QTc interval prolongation about 5 msec. The effects of postural change on the QT/QT...

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Bibliographic Details
Main Authors: Yutaka Kubo, MD, Shogo Murakami, MD, Kuniaki Otsuka, MD, Tsuyoshi Shiga, MD, Shin Irie, MD, Hiroshi Kasanuki, MD
Format: Article
Language:English
Published: Wiley 2005-01-01
Series:Journal of Arrhythmia
Subjects:
QT interval
Postural change
Heart rate correction formula
Nonpharmacological positive control
Online Access:http://www.sciencedirect.com/science/article/pii/S1880427605800158

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http://www.sciencedirect.com/science/article/pii/S1880427605800158

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