Modelling acute antibody-mediated rejection of human kidney transplants using ex-vivo warm machine perfusionResearch in context

Modelling acute antibody-mediated rejection of human kidney transplants using ex-vivo warm machine perfusionResearch in context

Summary: Background: Transplant rejection is a major cause of graft loss and morbidity. Currently, no human models of antibody-mediated rejection (AMR) exist, limiting mechanistic investigation and organ-specific targeted therapy. Here, using 12 human kidneys and ex-vivo normothermic machine perfus...

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Bibliographic Details
Main Authors: Pankaj Chandak, Benedict L. Phillips, Danothy Bennett, Raphael Uwechue, Nicos Kessaris, Olivia Shaw, Tim Maggs, Luke Woodford, David Veniard, Ranmith Perera, Kiran Parmar, Beverley J. Hunt, Chris Callaghan, Anthony Dorling, Nizam Mamode
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:EBioMedicine
Subjects:
Human kidney transplant model
Antibody-mediated rejection
Ex-vivo normothermic perfusion
HLA/ABO incompatible transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422005473

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http://www.sciencedirect.com/science/article/pii/S2352396422005473

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