Reduced early life mucosal integrity decreases thymic cell counts and increases local, but not thymic regulatory, T cell recruitment: Gut mucosal integrity breach and thymic T cells

Early life immune gut microbiota contact is critical for regulatory T cell–mediated oral tolerance induction. We induced a mucosal integrity breach with low dextran sulfate sodium dose right after weaning in BALB/c mice along with a standard high dose to study the impact of increased gut microbiota...

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Bibliographic Details
Main Authors: Hannah Louise Zakariassen, Katja Maria Bendtsen, Peter Tougaard, Axel Kornerup Hansen
Format: Article
Language:English
Published: SAGE Publishing 2019-01-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/2058739218823466