Gremlin-1 Promotes Colorectal Cancer Cell Metastasis by Activating ATF6 and Inhibiting ATF4 Pathways

Gremlin-1 Promotes Colorectal Cancer Cell Metastasis by Activating ATF6 and Inhibiting ATF4 Pathways

Cancer cell survival, function and fate strongly depend on endoplasmic reticulum (ER) proteostasis. Although previous studies have implicated the ER stress signaling network in all stages of cancer development, its role in cancer metastasis remains to be elucidated. In this study, we investigated th...

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Bibliographic Details
Main Authors: Ruohan Li, Huaixiang Zhou, Mingzhe Li, Qiuyan Mai, Zhang Fu, Youheng Jiang, Changxue Li, Yunfei Gao, Yunping Fan, Kaiming Wu, Clive Da Costa, Xia Sheng, Yulong He, Ningning Li
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
Gremlin-1
epithelial–mesenchymal transition
ATF4
ATF6
colorectal cancer
Online Access:https://www.mdpi.com/2073-4409/11/14/2136

Internet

https://www.mdpi.com/2073-4409/11/14/2136

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