Targeted Metabolomics of Organophosphate Pesticides and Chemical Warfare Nerve Agent Simulants Using High- and Low-Dose Exposure in Human Liver Microsomes

Targeted Metabolomics of Organophosphate Pesticides and Chemical Warfare Nerve Agent Simulants Using High- and Low-Dose Exposure in Human Liver Microsomes

Our current understanding of organophosphorus agent (pesticides and chemical warfare nerve agents) metabolism in humans is limited to the general transformation by cytochrome P450 enzymes and, to some extent, by esterases and paraoxonases. The role of compound concentrations on the rate of clearance...

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Bibliographic Details
Main Authors: Garima Agarwal, Hunter Tichenor, Sarah Roo, Thomas R. Lane, Sean Ekins, Craig A. McElroy
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Metabolites
Subjects:
LC-MS/MS
NMR
intrinsic clearance rate
cytochrome P450
metabolism
metabolite
Online Access:https://www.mdpi.com/2218-1989/13/4/495

Internet

https://www.mdpi.com/2218-1989/13/4/495

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