Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib

Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib

Background: Synovial fibroblasts (SF) play a major role in the pathogenesis of rheumatoid arthritis (RA) and develop an aggressive phenotype destroying cartilage and bone, thus termed RASF. JAK inhibitors have shown to be an efficient therapeutic option in RA treatment, but less is known about the e...

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Bibliographic Details
Main Authors: Magnus Diller, Rebecca Hasseli, Marie-Lisa Hülser, Iris Aykara, Klaus Frommer, Stefan Rehart, Ulf Müller-Ladner, Elena Neumann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
JAK inhibition
peficitinib
synovial fibroblast
rheumatoid arthritis
IL-1β
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00541/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00541/full

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