Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function

Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function

Abstract Background Neurodegenerative diseases encompass an extensive and heterogeneous group of nervous system disorders which are characterized by progressive degeneration and death of neurons. Many lines of evidence suggest the participation of mitochondria dysfunction in these diseases. Mitochon...

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Bibliographic Details
Main Authors: Xihui Chen, Fangfang Liu, Bowen Li, Yufeng Wang, Lijuan Yuan, Anan Yin, Qi Chen, Weihong Hu, Yan Yao, Mengjie Zhang, YuanMing Wu, Kun Chen
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Cell & Bioscience
Subjects:
Mitochondrial phenylalanyl-tRNA synthetase
Neurite outgrowth
Neurondegeneration
Mitochondrial dysfunction
Oxidative phosphorylation complexes
Zebrafish model
Online Access:https://doi.org/10.1186/s13578-022-00838-y

Internet

https://doi.org/10.1186/s13578-022-00838-y

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