Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities

Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities

The classic pathologic hallmarks of Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from individuals clinically diagnosed with “AD-type” (amnestic) dementia usually harbor heterogeneous neuropathologies in addition...

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Bibliographic Details
Main Authors: Yuriko Katsumata, Lincoln M. Shade, Timothy J. Hohman, Julie A. Schneider, David A. Bennett, Jose M. Farfel, Walter A. Kukull, David W. Fardo, Peter T. Nelson
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Neurobiology of Disease
Subjects:
NACC
SNP
Pleiotropy
PLCG2
ABCA7
APH1B
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122002728

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http://www.sciencedirect.com/science/article/pii/S0969996122002728

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