Effects of a peripherally acting µ-opioid receptor antagonist for the prevention of recurrent acute pancreatitis: study protocol for an investigator-initiated, randomized, placebo-controlled, double-blind clinical trial (PAMORA-RAP trial)

Effects of a peripherally acting µ-opioid receptor antagonist for the prevention of recurrent acute pancreatitis: study protocol for an investigator-initiated, randomized, placebo-controlled, double-blind clinical trial (PAMORA-RAP trial)

Abstract Background Acute and chronic pancreatitis constitute a continuum of inflammatory disease of the pancreas with an increasing incidence in most high-income countries. A subset of patients with a history of pancreatitis suffer from recurrence of acute pancreatitis attacks, which accelerate dis...

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Bibliographic Details
Main Authors: Mathias E. Cook, Cecilie S. Knoph, Camilla A. Fjelsted, Jens B. Frøkjær, Anders E. Bilgrau, Srdan Novovic, Maiken Thyregod Jørgensen, Michael B. Mortensen, Liv B. J. Nielsen, Amer Hadi, Mark Berner-Hansen, Wiktor Rutkowski, Miroslav Vujasinovic, Matthias Löhr, Asbjørn M. Drewes, Søren S. Olesen
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Trials
Subjects:
Peripherally acting µ-opioid receptor antagonist
Recurrent acute pancreatitis
Randomized controlled trial
Naldemedine
Opioid
Magnetic resonance imaging
Online Access:https://doi.org/10.1186/s13063-023-07287-z

Internet

https://doi.org/10.1186/s13063-023-07287-z

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