Anthrax protective antigen is a calcium-dependent serine protease
Bacillus anthracis secretes a three component exotoxin-complex, which contributes to anthrax pathogenesis. Formation of this complex starts with the binding of protective antigen (PA) to its cellular receptor. In this study, we report that PA is a calcium-dependent serine protease and that the prote...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21505594.2018.1486139 |
| _version_ | 1811277865005613056 |
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| author | Lisanne Storm Floris J. Bikker Kamran Nazmi Albert G. Hulst Debora V. der Riet-Van Oeveren Enno C.I. Veerman John P. Hays Wendy E. Kaman |
| author_facet | Lisanne Storm Floris J. Bikker Kamran Nazmi Albert G. Hulst Debora V. der Riet-Van Oeveren Enno C.I. Veerman John P. Hays Wendy E. Kaman |
| author_sort | Lisanne Storm |
| collection | DOAJ |
| description | Bacillus anthracis secretes a three component exotoxin-complex, which contributes to anthrax pathogenesis. Formation of this complex starts with the binding of protective antigen (PA) to its cellular receptor. In this study, we report that PA is a calcium-dependent serine protease and that the protein potentially uses this proteolytic activity for receptor binding. Additionally our findings shed new light on previous research describing the inhibition of anthrax toxins and exotoxin formation. Importantly, inhibition of the proteolytic activity of protective antigen could be a novel therapeutic strategy in fighting B. anthracis-related infections. |
| first_indexed | 2024-04-13T00:25:36Z |
| format | Article |
| id | doaj.art-51ce78c8294045e09ecf67068c8d8723 |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-04-13T00:25:36Z |
| publishDate | 2018-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-51ce78c8294045e09ecf67068c8d87232022-12-22T03:10:38ZengTaylor & Francis GroupVirulence2150-55942150-56082018-12-01911085109110.1080/21505594.2018.14861391486139Anthrax protective antigen is a calcium-dependent serine proteaseLisanne Storm0Floris J. Bikker1Kamran Nazmi2Albert G. Hulst3Debora V. der Riet-Van Oeveren4Enno C.I. Veerman5John P. Hays6Wendy E. Kaman7Erasmus University Medical CentreUniversity of Amsterdam and VU University AmsterdamUniversity of Amsterdam and VU University AmsterdamNetherlands Organization for Applied Scientific Research TNONetherlands Organization for Applied Scientific Research TNOUniversity of Amsterdam and VU University AmsterdamErasmus University Medical CentreErasmus University Medical CentreBacillus anthracis secretes a three component exotoxin-complex, which contributes to anthrax pathogenesis. Formation of this complex starts with the binding of protective antigen (PA) to its cellular receptor. In this study, we report that PA is a calcium-dependent serine protease and that the protein potentially uses this proteolytic activity for receptor binding. Additionally our findings shed new light on previous research describing the inhibition of anthrax toxins and exotoxin formation. Importantly, inhibition of the proteolytic activity of protective antigen could be a novel therapeutic strategy in fighting B. anthracis-related infections.http://dx.doi.org/10.1080/21505594.2018.1486139Protective antigenB. anthraciscalciumserine proteaseANTXR1/2 receptor |
| spellingShingle | Lisanne Storm Floris J. Bikker Kamran Nazmi Albert G. Hulst Debora V. der Riet-Van Oeveren Enno C.I. Veerman John P. Hays Wendy E. Kaman Anthrax protective antigen is a calcium-dependent serine protease Virulence Protective antigen B. anthracis calcium serine protease ANTXR1/2 receptor |
| title | Anthrax protective antigen is a calcium-dependent serine protease |
| title_full | Anthrax protective antigen is a calcium-dependent serine protease |
| title_fullStr | Anthrax protective antigen is a calcium-dependent serine protease |
| title_full_unstemmed | Anthrax protective antigen is a calcium-dependent serine protease |
| title_short | Anthrax protective antigen is a calcium-dependent serine protease |
| title_sort | anthrax protective antigen is a calcium dependent serine protease |
| topic | Protective antigen B. anthracis calcium serine protease ANTXR1/2 receptor |
| url | http://dx.doi.org/10.1080/21505594.2018.1486139 |
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