circNOX4 activates an inflammatory fibroblast niche to promote tumor growth and metastasis in NSCLC via FAP/IL-6 axis

circNOX4 activates an inflammatory fibroblast niche to promote tumor growth and metastasis in NSCLC via FAP/IL-6 axis

Abstract Background Cancer-associated fibroblasts (CAFs) orchestrate a supportive niche that fuels cancer metastatic development in non-small cell lung cancer (NSCLC). Due to the heterogeneity and plasticity of CAFs, manipulating the activated phenotype of fibroblasts is a promising strategy for can...

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Bibliographic Details
Main Authors: Yan Zhao, Yunlong Jia, Jiali Wang, Xiaolin Chen, Jingya Han, Shuman Zhen, Shuxian Yin, Wei Lv, Fan Yu, Jiaqi Wang, Fan Xu, Xinming Zhao, Lihua Liu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Molecular Cancer
Subjects:
NSCLC
CAFs
circNOX4
FAP
IL-6
Metastasis
Online Access:https://doi.org/10.1186/s12943-024-01957-5

Internet

https://doi.org/10.1186/s12943-024-01957-5

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