Drug Holiday of Interferon Beta 1b in Multiple Sclerosis: A Pilot, Randomized, Single Blind Study of Non-inferiority

Drug Holiday of Interferon Beta 1b in Multiple Sclerosis: A Pilot, Randomized, Single Blind Study of Non-inferiority

Introduction: To compare a schedule with cyclic withdrawal (CW) of interferon beta (IFN-b) 1b, respect to the full regimen (FR), in relapsing-remitting MS (RR-MS).Methods: Participants were randomly assigned to CW or FR schedule and monthly monitored with brain MRI scans for 12 months (three of run-...

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Bibliographic Details
Main Authors: Silvia Romano, Michela Ferraldeschi, Francesca Bagnato, Rosella Mechelli, Emanuele Morena, Marzia Caldano, Maria Chiara Buscarinu, Arianna Fornasiero, Marco Frontoni, Viviana Nociti, Massimiliano Mirabella, Flavia Mayer, Antonio Bertolotto, Carlo Pozzilli, Nicola Vanacore, Marco Salvetti, Giovanni Ristori
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neurology
Subjects:
relapsing-remitting multiple sclerosis
interferon beta 1b
non-inferiority
cyclic withdrawal
contrast-enhanced lesions
black holes
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00695/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.00695/full

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