Origin recognition complex subunit 6 (ORC6) is a key mediator of LPS-induced NFκB activation and the pro-inflammatory response

Origin recognition complex subunit 6 (ORC6) is a key mediator of LPS-induced NFκB activation and the pro-inflammatory response

Abstract Lipopolysaccharide (LPS)-activated pro-inflammatory responses play a critical role in sepsis, a life-threatening condition. This study investigates the role of origin recognition complex subunit 6 (ORC6) in LPS responses in macrophages and monocytes. Silencing ORC6 using targeted shRNA sign...

Full description

Bibliographic Details
Main Authors: Zichen Xie, Haisu Lu, Jiayi Zheng, Jianfeng Song, Keyu Sun
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Cell Communication and Signaling
Subjects:
ORC6
LPS
NFκB
Pro-inflammatory response
Macrophages and monocytes
Online Access:https://doi.org/10.1186/s12964-024-01768-7

Internet

https://doi.org/10.1186/s12964-024-01768-7

Similar Items