Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway

Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway

Context Veratramine may have a potential therapeutic effect for diabetic peripheral neuropathy (DPN).Objective To evaluate whether veratramine ameliorates neuropathic pain in a rat diabetic model.Materials and methods Sprague–Dawley rats were used for a diabetic model induced by a streptozotocin + h...

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Bibliographic Details
Main Authors: Yu Zhang, Guangyao Ye, Yuebo Chen, Chaoxu Sheng, Jianlin Wang, Lingsi Kong, Liyong Yuan, Chunyan Lin
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Pharmaceutical Biology
Subjects:
Neuropathic pain
high-fat diet
mechanical withdrawal threshold
coimmunoprecipitation
sciatic nerve pathological injury
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2022.2136207

Internet

https://www.tandfonline.com/doi/10.1080/13880209.2022.2136207

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