A Library Screening Strategy Combining the Concepts of MS Binding Assays and Affinity Selection Mass Spectrometry

The primary objective of early drug development is to identify hits and leads for a target of interest. To achieve this aim, rapid, and reliable screening techniques for a huge number of compounds are needed. Mass spectrometry based binding assays (MS Binding Assays) represent a well-established tec...

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Bibliographic Details
Main Authors: Jürgen Gabriel, Georg Höfner, Klaus T. Wanner
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00665/full