Potencies of cocaine methiodide on major cocaine targets in mice.

Cocaine methiodide (CM), a charged cocaine analog, cannot pass the blood brain barrier. It has been assumed the effects of systemic CM represent cocaine actions in peripheral tissues. However, the IC(50) values of CM have not been clearly determined for the major cocaine targets: dopamine, norepinep...

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Bibliographic Details
Main Authors: Erik R Hill, Jinbin Tian, Michael R Tilley, Michael X Zhu, Howard H Gu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2762027?pdf=render