A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis

A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis

Abstract Background Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the lungs. Activated differentiation of progenitor cells, which are mainly resident fibroblasts, into myofibroblasts is considered a key mechanism un...

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Bibliographic Details
Main Authors: Hiroshi Kasamatsu, Takenao Chino, Takumi Hasegawa, Natsuko Utsunomiya, Akira Utsunomiya, Masami Yamada, Noritaka Oyama, Minoru Hasegawa
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
Skin
Lung
Calpain
Cysteine proteinase inhibitor
TGF-β
Online Access:https://doi.org/10.1186/s13075-023-03130-7

Internet

https://doi.org/10.1186/s13075-023-03130-7

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