AKR1C1/2 inhibition by MPA sensitizes platinum resistant ovarian cancer towards carboplatin

AKR1C1/2 inhibition by MPA sensitizes platinum resistant ovarian cancer towards carboplatin

Abstract In recurrent epithelial ovarian cancer (EOC) most patients develop platinum-resistance. On molecular level the NRF2 pathway, a cellular defense mechanism against reactive oxygen species, is induced. In this study, we investigate AKR1C1/2, target of NRF2, in a well-established EOC collective...

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Bibliographic Details
Main Authors: Susann Badmann, Doris Mayr, Elisa Schmoeckel, Anna Hester, Christina Buschmann, Susanne Beyer, Thomas Kolben, Fabian Kraus, Anca Chelariu-Raicu, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-05785-9

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https://doi.org/10.1038/s41598-022-05785-9

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